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RV-001
RV-001
Next-generation Vasodilator Platform
: Light–Activated Nitric Oxide (NO) Delivery
The Growing Burden of Vascular Occlusion
The Growing Burden of Vascular Occlusion
Peripheral arterial disease: +10% annually
Coronary artery disease: +50% over 10 years
Cerebrovascular disease: continuously increasing
📈
⚠️
Limitations of Current Treatments
Limitations of Current Treatments
Stents: 20–30% restenosis risk
Balloon angioplasty: temporary effect
Anticoagulants: bleeding risks
Drug therapy: no fundamental solution
VINO BIO delivers a next-generation solution.
VINO BIO delivers a next-generation solution.
" A Light-Activated Nitric Oxide Delivery System "
1
1
Stable Metal–NO Carrier
Stable Metal–NO Carrier
Prevents unintended NO release and ensures safe systemic circulation
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2
Light Activation
Light Activation
Upon irradiation, NO is selectively dissociated and delivered at the target site
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3
Controlled NO Release
Controlled NO Release
Unlike conventional NO donors that release spontaneously, this system minimizes side effects by enabling site-specific and regulated release
Experimental Validation
X 1.59
X 1.59
Increase in Vessel Diameter
Significant vasodilation achieved via light-triggered NO release
Validated through in vivo imaging analysis
85%
85%
Blood Flow Recovery
Restored perfusion in retinal vascular occlusion model
Demonstrates functional recovery beyond structural expansion
Publications
Angew. Chem. Int. Ed. 2019, 58, 10126
Chem 2023, 9, 1309
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